小林　宏祐講師

博士 (獣医学)

研究者情報（researchmap）：https://researchmap.jp/k_kobayashi1211/

イヌ悪性腫瘍，血液凝固障害

• イヌの血液凝固障害の病態の解明および新規診断・治療法の確立を目指した研究
• スタチン系薬剤の抗腫瘍作用および抗凝固作用に関する研究
• イヌ悪性腫瘍に対する新規治療法の探索

1. Kobayashi K, Baba K, Kambayashi S, Okuda M. Blockade of isoprenoids biosynthesis by simvastatin induces autophagy-mediated cell death via downstream c-Jun N-terminal kinase activation and cell cycle dysregulation in canine T-cell lymphoma cells. Res Vet Sci. 2024 Mar:169:105174.
2. Kobayashi K, Takemura RD, Miyamae J, Mitsui I, Murakami K, Kutara K, Saeki K, Kanda T, Okamura Y, Sugiyama A. Phenotypic and molecular characterization of novel pulmonary adenocarcinoma cell lines established from a dog. Sci Rep. 2023 Oct 5;13(1):16823.
3. Kobayashi K, Baba K, Kambayashi S, Okuda M. Effect of simvastatin on cell proliferation and Ras activation in canine tumour cells. Vet Comp Oncol. 2021 Mar;19(1):99-108.
4. Kobayashi K, Baba K, Igase M, Miyama TS, Kambayashi S, Okuda M. Microparticle-associated tissue factor activity in dogs with disseminated intravascular coagulation. J Vet Med Sci. 82(1):56-60. 2020.
5. Kobayashi K, Baba K, Igase M, Primarizky H, Nemoto Y, Shimokawa Miyama T, Kambayashi S, Mizuno T, Okuda M. Tissue factor procoagulant activity in the tumor cell lines and plasma of dogs with various malignant tumors. J Vet Med Sci. 81(12):1713-1721. 2019.
6. Kobayashi K, Shimokawa Miyama T, Itamoto K, Noguchi S, Baba K, Mizuno T, Okuda M. Development of hepatocellular carcinoma after long-term immunosuppressive therapy including danazol in a dog. J Vet Med Sci. 78(10):1611-1614. 2016.