邊見　弘明教授

博士（医学）

免疫学、免疫応答、炎症、自然免疫、樹状細胞

• 各種免疫応答、免疫・炎症性疾患の分子メカニズムの解明
• 抗原提示細胞による免疫制御機構の解析
• 遺伝子改変マウスを用いた免疫機構の解析、各種疾患の病態解明

1. Ohta T, Sugiyama M, Hemmi H, Yamazaki C, Okura S, Sasaki I, Fukuda Y, Orimo T, Ishii KJ, Hoshino K, Ginhoux F, Kaisho T. Crucial roles of XCR1-expressing dendritic cells and the XCR1-XCL1 chemokine axis in intestinal immune homeostasis. Sci Rep. 6: 23505, 2016.
2. Yamazaki C, Sugiyama M, Ohta T, Hemmi H, Hamada E, Sasaki I, Fukuda Y, Yano T, Nobuoka M, Hirashima T, Iizuka A, Sato K, Tanaka T, Hoshino K, Kaisho T. Critical roles of a dendritic cell subset expressing a chemokine receptor, XCR1. J Immunol. 190: 6071-6782, 2013.
3. Hemmi H, Zaidi N, Wang B, Matos I, Fiorese C, Lubkin A, Zbytnuik L, Suda K, Zhang K, Noda M, Kaisho T, Steinman RM, Idoyaga J. Treml4, an Ig Superfamily Member, Mediates Presentation of Several Antigens to T Cells In Vivo, Including Protective Immunity to HER2 Protein. J Immunol. 188: 1147-1155, 2012.
4. Hemmi H, Idoyaga J, Suda K, Suda N, Kennedy K, Noda M, Aderem A, Steinman RM. A New Triggering Receptor Expressed on Myeloid Cells (Trem) Family Member, Trem-like 4, Binds to Dead Cells and Is a DNAX Activation Protein 12-linked Marker for Subsets of Mouse Macrophages and Dendritic Cells. J Immunol. 182: 1278-1286, 2009.
5. Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, Matsumoto M, Hoshino K, Wagner H, Takeda K, Akira S. A Toll-like receptor recognizes bacterial DNA. Nature. 408:740-745, 2000.