岡山理科大学獣医学部

研究・教員紹介

HOME研究・教員紹介早川 晃司

早川 晃司講師

学位
博士(農学)
https://researchmap.jp/kojihayakawa/

専門分野

エピジェネティクス

研究分野

クロマチン制御、ヒストン修飾、DNA修飾、多倍体核、ゲノム進化

研究内容

  •  栄養環境に依存したクロマチン制御の解明
  • ヒストンO-GlcNAc修飾の機能解明
  • 多倍体核のクロマチン制御の解明

研究業績

  1. Hayakawa K, Terada K, Takahashi T, Oana H, Washizu M, Tanaka S. Nucleosomes of polyploid trophoblast giant cells mostly consist of histone variants and form a loose chromatin structure. Sci Rep. 2018 Apr 11;8(1):5811.
  2. Hayakawa K, Hirosawa M, Tani R, Yoneda C, Tanaka S, Shiota K. H2A O-GlcNAcylation at serine 40 functions genomic protection in association with acetylated H2AZ or γH2AX. Epigenetics Chromatin. 2017 Oct 30;10(1):51.
  3. Hayakawa K, Sakamoto Y, Kanie O, Ohtake A, Daikoku S, Ito Y, Shiota K. Reactivation of hyperglycemia-induced hypocretin (HCRT) gene silencing by N-acetyl-D-mannosamine in the orexin neurons derived from human iPS cells. Epigenetics. 2017 Sep;12(9):764-778.
  4. Hirosawa M*, Hayakawa K*, Yoneda C, Arai D, Shiota H, Suzuki T, Tanaka S, Dohmae N, Shiota K. Novel O-GlcNAcylation on Ser(40) of canonical H2A isoforms specific to viviparity. Sci Rep. 2016 Sep 12;6:31785.(*, equally contributed author)
  5. Hayakawa K, Hirosawa M, Tabei Y, Arai D, Tanaka S, Murakami N, Yagi S, Shiota K. Epigenetic switching by the metabolism-sensing factors in the generation of orexin neurons from mouse embryonic stem cells. J Biol Chem. 2013 Jun 14;288(24):17099-110.
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