小野　岳人講師

博士（医学）、歯科医師免許

https://researchmap.jp/ononotakehito

• 免疫系による骨形成制御機構の解明
• 運動を模倣して筋や骨の疾患を治療する薬物の開発
• 咀嚼力や矯正力が顎骨リモデリングを誘導するメカニズムの解明

1. Yifan Qing, Takehito Ono*, Yukihiro Kohara, Atsushi Watanabe, Noboru Ogiso, Masako Ito, Tomoki Nakashima, Sunao Takeshita; Emilin2 marks the target region for mesenchymal cell accumulation in bone regeneration; Inflamm. Regen., 44(1) 27 (2024)
2. Naomi Toyama, Takehito Ono*, Takashi Ono, Tomoki Nakashima; The interleukin-6 signal regulates orthodontic tooth movement and pain; Biochem. Biophys. Res. Commun., 684 149068 (2023)
3. Takehito Ono*, Ryosuke Denda, Yuta Tsukahara, Takashi Nakamura, Kazuo Okamoto, Hiroshi Takayanagi, Tomoki Nakashima; Simultaneous augmentation of muscle and bone by locomomimetism through calcium-PGC-1α signaling; Bone Res., 10(1) 52 (2022)
4. Lin Liu, Hiroyuki Koike, Takehito Ono*, Shinichiro Hayashi, Fujimi Kudo, Atsushi Kaneda, Hiroyuki Kagechika, Ichiro Manabe, Tomoki Nakashima, Yumiko Oishi; Identification of a KLF5-dependent program and drug development for skeletal muscle atrophy; Proc. Natl. Acad. Sci. U.S.A., 118(35) (2021)
5. Takehito Ono*, Kazuo Okamoto, Tomoki Nakashima, Takeshi Nitta, Shohei Hori, Yoichiro Iwakura, Hiroshi Takayanagi; IL-17-producing γδ T cells enhance bone regeneration; Nat. Commun., 7 10928 (2016)