齋藤 文代准教授

学位

専門分野

毒性学

研究分野

肝毒性、腎毒性、トランスクリプトーム解析、遺伝子ネットワーク解析、ゲノム解析、DNA/RNA修飾

研究内容

・医薬品や化学物質による肝毒性および腎毒性メカニズムの解明

 

・疾患関連遺伝子のネットワーク解析

 

・老化に関与するDNAおよびRNA修飾の解明

研究業績

  1. Matsui T, Miyamoto N, Saito F, Shinozawa T. Molecular Profiling of Human Induced Pluripotent Stem Cell Derived Cells and Their Application for the Drug Safety Study. Curr Pharm Biotechnol. 2020, 21(9).
  2. Saito F. Mechanism-Based Evaluation System for Hepato- and Nephrotoxicity or Carcinogenicity Using Omics Technology. Alternatives to Animal Testing. 2018, 91-104.
  3. Matsumoto H*, Saito F*, Takeyoshi M. Investigation of the early-response genes in chemical-induced renal carcinogenicity for the prediction of chemical carcinogenicity in rats. J Toxicol Sci. 2017;42(2):175-181. (*, equally contributed author)
  4. Saito F, Matsumoto H, Akahori Y, Takeyoshi M. Simpler alternative to CARCINOscreen® based on quantitative PCR (qPCR). J Toxicol Sci. 2016, 41(3):383-90.
  5. Abe H, Saito F, Tanaka T, Mizukami S, Watanabe Y, Imatanaka N, Akahori Y, Yoshida T, Shibutani M*. Global gene expression profiles in brain regions reflecting abnormal neuronal and glial functions targeting myelin sheaths after 28-day exposure to cuprizone in rats. Toxicol Appl Pharmacol. 2016, 310:20-31.

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