梶川　修平助教

博士（歯学）

研究者情報（researchmap）: https://researchmap.jp/s-kajikawa

科研費データベース：https://nrid.nii.ac.jp/ja/nrid/1000060846848/

骨細胞生物学

がん

遺伝子改変マウスや細胞を使い、主に以下の研究テーマを進行中

• 骨における12型コラーゲンの機能解析
• 骨肉腫における12型コラーゲンの役割の検討
• アクチン骨格制御因子Profilin1の骨関連細胞における機能解明と骨疾患治療標的としての可能性の検討

1. Zhu Ling, Hailati Aini, Shuhei Kajikawa, Jumpei Shirakawa, Kunikazu Tsuji, Yoshinori Asou, Hideyuki Koga, Ichiro Sekiya, Akira Nifuji, Masaki Noda, Yoichi Ezura. Osteolytic Bone Loss and Skeletal Deformities in a Mouse Model for Early-Onset Paget's Disease of Bone with PFN1 Mutation Are Treatable by Alendronate. Pharmaceuticals. 2023 Oct 2;16(10):1395.
2. Shuhei Kajikawa, Yoichi Ezura, Yayoi Izu, Kazuhisa Nakashima, Masaki Noda, Akira Nifuji. Profilin-1 negatively controls osteoclast migration by suppressing the protrusive structures based on branched actin filaments. J Bone Miner Metab. 2022 Jul;40(4):561-570.
3. Shohei Otani, Yuki Date, Tomoya Ueno, Tomoko Ito, Shuhei Kajikawa, Keisuke Omori, Ichiro Taniuchi, Masahiro Umeda, Toshihisa Komori, Junya Toguchida, Kosei Ito. Runx3 is required for oncogenic Myc upregulation in p53-deficient osteosarcoma. Oncogene. 2022 Jan;41(5):683-691.
4. Jumpei Shirakawa*, Shuhei Kajikawa*, Ralph T Böttcher, Mercedes Costell, Yayoi Izu, Tadayoshi Hayata, Masaki Noda, Yoichi Ezura. *These authors contributed equally to this work. Profilin 1 Negatively Regulates Osteoclast Migration in Postnatal Skeletal Growth, Remodeling, and Homeostasis in Mice. JBMR Plus. 3:e10130 (2019).
5. Shuhei Kajikawa, Yuu Taguchi, Tadayoshi Hayata, Yoichi Ezura, Ryo Ueta, Sumimasa Arimura, Jun-ichiro Inoue, Masaki Noda, Yuji Yamanashi. Dok-3 and Dok-1/-2 adaptors play distinctive roles in cell fusion and proliferation during osteoclastogenesis and cooperatively protect mice from osteopenia. Biophys. Res. Commun. 498, 967-974 (2018)