学位
専門分野
タンパク質脱リン酸化酵素、腫瘍、がん幹細胞、オートファジー
研究内容
タンパク質脱リン酸化酵素によるがん幹細胞の制御機構の解明
タンパク質脱リン酸化酵素とオートファジーの相互作用機構の解明
大腸がんに対する新規治療戦略の開発
研究業績
- Fujiwara N, Usui T, Ohama T, Sato K. Regulation of Beclin 1 Protein Phosphorylation and Autophagy by Protein Phosphatase 2A (PP2A) and Death-associated Protein Kinase 3 (DAPK3). J Biol Chem. 13;291(20):10858-66. 2016
- Usui T, Sakurai M, Enjoji S, Kawasaki H, Umata K, Ohama T, Fujiwara N, Yabe R, Tsuji S, Yamawaki H, Hazama S, Takenouchi H, Nakajima M, Tsunedomi R, Suzuki N, Nagano H, Sato K. Establishment of a Novel Model for Anticancer Drug Resistance in Three-Dimensional Primary Culture of Tumor Microenvironment. Stem Cells Int. 2016:7053872. 2016
- The therapeutic effects of SET/I2PP2A inhibitors on canine melanoma. Enjoji S, Yabe R, Fujiwara N, Tsuji S, Vitek MP, Mizuno T, Nakagawa T, Usui T, Ohama T, Sato K. J Vet Med Sci. 77(11):1451-6. 2015
- Yabe R, Fujiwara N, Mizuno T, Usui T, Ohama T, Sato K. Characterization of SET/I2PP2A isoforms in dogs. J Vet Med Sci. 76(9):1235-40.2014
- Fujiwara N, Kawasaki H, Yabe R, Christensen DJ, Vitek MP, Mizuno T, Sato K, Ohama T. A potential therapeutic application of SET/I2PP2A inhibitor OP449 for canine T-cell lymphoma. J Vet Med Sci. ;75(3):349-54. 2013